EFSA’s Scientific Committee first developed guidance on the use of the benchmark dose (BMD) approach in EFSA’s risk assessments as an alternative to the traditional No-Observed-Adverse-Effect-Level (NOAEL) approach, in 2009. A 2017 update mainly concerned how to apply the BMD approach in practice and model averaging was introduced to account for model uncertainty. Following an EFSA workshop in March 2017 to discuss commonalities and divergences in the various approaches for BMD analysis worldwide, and the update of Chapter 5 on dose– response assessment of WHO/IPCS Environmental Health Criteria 240 (WHO, 2020), the Scientific Committee decided to update its guidance again to align it with internationally agreed concepts related to benchmark dose analysis, introducing Bayesian model averaging and a harmonised set of dose-response models for continuous and quantal responses, further harmonising EFSA’s approach with its partners.

The latest updated Guidance was published on 25 October 2022.

The event will be divided in two parts:

• Presentation of the new guidance, changes to the previous version, and EFSA’s recommended approach for BMD analysis.
• Illustration of the new approach, using the EFSA BMD analysis platform with pesticides-related case studies.

During the event, the audience will have the opportunity to submit questions to the speakers and interact with the presenters.

A műhelytalálkozó személyes rendezvény (Brüsszel) formájában kerül megrendezésre.

Registration to this event is open to risk assessors and all stakeholders involved or interested in the use of the benchmark dose (BMD) approach in risk assessment.

Regisztrációs határidő: 9 January 2023, 12:00.